Manipram 20 Mg 14 Tablets

Product overview:

Product form: Tablets

Pack size: 14s

Manufactured by: Werrick Pharmaceuticals

Prescription: Yes

Product Details

Manipram 20 mg Tablets contain Citalopram HBr, a selective serotonin reuptake inhibitor (SSRI) commonly used to treat depression. The antidepressant effects of citalopram are believed to be linked to the enhancement of serotonin activity in the central nervous system (CNS). By inhibiting the reuptake of serotonin (5-HT) in neurons, citalopram increases the availability of this neurotransmitter, which helps improve mood and emotional stability. Citalopram is particularly known for its specificity in targeting serotonin pathways, with minimal effects on norepinephrine (NE) and dopamine (DA) reuptake.

Purposes

Manipram 20 mg Tablets are prescribed for the management of:

• Depressive Disorders: Including both endogenous (internally caused) and non-endogenous depression. This medication is effective in alleviating symptoms such as persistent sadness, loss of interest in activities, and other emotional disturbances associated with depression.

Warnings

1. Risk of Suicidality: Antidepressants like Manipram may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults, particularly during the initial treatment period or when adjusting the dose. This risk must be carefully weighed against the clinical need in these age groups.
2. Close Monitoring: Patients of all ages who start treatment with Manipram should be closely monitored for any signs of worsening depression, suicidal thoughts, or unusual changes in behavior, especially during the first few months of therapy.
3. Family and Caregiver Vigilance: Families and caregivers should maintain close communication with the prescriber and observe the patient closely for any behavioral changes. Manipram is not approved for use in pediatric patients.

Adverse Effects

Common side effects associated with Manipram 20 mg Tablets include:

• Gastrointestinal Upset: Such as nausea, vomiting, and diarrhea.
• Tremor: Involuntary shaking, particularly in the hands.
• Somnolence: Increased drowsiness or sleepiness.
• Dry Mouth: A common side effect of many SSRIs.
• Anxiety and Agitation: Some patients may experience increased anxiety or restlessness, particularly when starting treatment.
• Sweating: Increased sweating may occur, especially during physical exertion or in warm environments.
• Sexual Dysfunction: Such as decreased libido or impotence.
• Serotonin Syndrome: A potentially life-threatening condition that can occur with the use of serotonergic drugs. Symptoms include high fever, agitation, increased reflexes, tremors, sweating, dilated pupils, and diarrhea.

Drug Interactions

Manipram may interact with several other medications, including but not limited to:

• Monoamine Oxidase Inhibitors (MAOIs): Combining these with Manipram can lead to serious and potentially fatal reactions.
• Other Serotonergic Drugs: Including other SSRIs, SNRIs, 5HT1 agonists, and St. John's Wort, which can increase the risk of serotonin syndrome.
• CYP2D6 Substrates: Such as metoprolol, which can have altered effects when taken with Manipram.
• Drugs that Prolong QT Interval: Such as certain antipsychotics and antiarrhythmics, which can increase the risk of heart-related side effects.

Always inform your healthcare provider about all medications and supplements you are taking to avoid harmful interactions.

Cautions

• Monitoring: All patients should be monitored closely, especially during the initial phases of treatment, for any signs of worsening depression, suicidality, or unusual behavior changes.
• Hypersensitivity: Do not use Manipram if you have a known allergy to citalopram or any of the ingredients in the formulation. If you experience any allergic reactions, such as rash, itching, swelling, or difficulty breathing, seek medical attention immediately.

Pregnancy and Breastfeeding

Consult your physician before using Manipram Tablets if you are pregnant, planning to become pregnant, or breastfeeding. The safety of citalopram during pregnancy and lactation has not been fully established, and it should only be used if prescribed by a healthcare provider.

Storage Instructions

Store Manipram 20 mg Tablets at room temperature, away from direct light and heat. Keep this medication out of reach of children to prevent accidental ingestion.