Xarelto (Rivaroxaban) Tablets 20mg are a highly effective anticoagulant designed to prevent blood clots, particularly after major surgeries such as leg operations. The active ingredient, Rivaroxaban, selectively inhibits Factor Xa, disrupting the blood coagulation process and preventing the formation of thrombi. Unlike other anticoagulants, Rivaroxaban specifically targets Factor Xa and does not affect platelets or thrombin.
Purposes
Xarelto is primarily used to prevent blood clots in veins following major leg surgeries. Its mechanism of action involves interrupting both the intrinsic and extrinsic pathways of blood coagulation, making it an essential medication for post-operative care in high-risk patients.
Warnings
Renal Impairment: Caution is advised for patients with creatinine clearance between 15 - 29 ml/min. Xarelto is not recommended for patients with creatinine clearance below this level.
Prosthetic Heart Valves: The use of Xarelto is not recommended for patients with prosthetic heart valves.
Cancer Patients: Patients with active cancer, especially those with tumors in the gastrointestinal or genitourinary tract, may have an increased risk of bleeding during Xarelto therapy. The benefits of treatment should be carefully weighed against the potential risks.
Adverse Effects
Common side effects include post-operative bleeding, anemia, and nausea. Less commonly, patients may experience bleeding in the stomach or bowel, nosebleeds, and hematomas. Rare side effects include impaired liver function and allergic skin reactions. It is crucial to monitor for signs of bleeding throughout treatment.
Cautions
Bleeding Risk: Patients should be carefully observed for signs of bleeding, particularly if they have conditions that increase hemorrhage risk. Xarelto should be discontinued if severe bleeding occurs.
Drug Interactions: Xarelto may interact with antifungal medications (e.g., ketoconazole), HIV/AIDS medications (e.g., ritonavir), and other blood-thinning agents (e.g., enoxaparin, clopidogrel).
Additional Information
Pregnancy: Always consult your physician before using this medication during pregnancy.
Storage: Store Xarelto Tablets at room temperature, away from direct light and heat.
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