Danzol Capsules 100mg

Danzol Capsules Specification

✔ Requires Prescription (YES/NO): Yes
✔ Generics: Danazol
✔ Used For: Endometriosis, Fibrocystic Breast Disease

How It Works

Danzol Capsules 100mg contain Danazol, a synthetic steroid derived from ethisterone. It exhibits multiple pharmacological actions, including:

1. Hormonal Modulation: Interacts with androgen, progesterone, and estrogen receptors, reducing endometriotic tissue growth.
2. Suppression of Gonadal Steroid Synthesis: Inhibits key enzymes like 3ß hydroxysteroid dehydrogenase and 17ß hydroxysteroid dehydrogenase, reducing estrogen production.
3. Regulation of Gonadotropins: Decreases FSH and LH levels, leading to hormonal balance and symptom relief.
4. Effect on Plasma Proteins: Alters levels of fibrinogen, thyroid-binding globulin, and sex hormone-binding globulin, increasing unbound testosterone levels.
5. Reversible Effects: The suppressive impact on the hypothalamic-pituitary-gonadal axis is temporary, with normal function resuming within 60-90 days after stopping treatment.

Danzol Capsules Usage and Safety

Dosage

✔ Generic Name: Danazol
✔ Dosage Form: Oral Capsules
✔ Recommended Use: As prescribed by a healthcare professional

Side Effects

Possible side effects may include:
✔ Skin Reactions: Acne, pigmentation changes, exfoliative dermatitis, Stevens-Johnson syndrome
✔ Allergic Reactions: Urticaria (hives), pruritus (itching), nasal congestion
✔ Gastrointestinal Issues: Nausea, vomiting, constipation, gastroenteritis, rare pancreatitis
✔ Genitourinary Effects: Hematuria (blood in urine), menstrual irregularities, prolonged amenorrhea (absence of menstruation)

Drug Interactions

Danzol Capsules may interact with:
❌ Anticoagulants (e.g., Warfarin) – May alter blood clotting time
❌ Anticonvulsants (e.g., Carbamazepine, Phenytoin, Phenobarbital) – May affect drug metabolism
❌ Immunosuppressants (e.g., Cyclosporine, Tacrolimus) – May increase toxicity risk
❌ Diabetes Medications (e.g., Insulin, Oral Hypoglycemics) – Can affect blood sugar control
❌ Antihypertensive Drugs – May reduce effectiveness
❌ Statins (e.g., Simvastatin, Atorvastatin, Lovastatin) – Co-administration with Simvastatin is contraindicated

Indications

Danzol Capsules are primarily used for:
✔ Endometriosis Treatment: Reduces pelvic pain and tissue overgrowth
✔ Fibrocystic Breast Disease: Relieves breast pain and cyst formation
✔ Menstrual Disorders: Helps in managing irregular cycles

When Not to Use

Danzol Capsules should not be used in patients with:
🚫 Undiagnosed abnormal genital bleeding
🚫 Genital neoplasia (cancer)
🚫 Severe liver, kidney, or heart disease
🚫 Pregnancy or breastfeeding (potential androgenic effects on infants)
🚫 Porphyria – Can trigger acute intermittent porphyria
🚫 Active thrombosis or thromboembolic history
🚫 Hypersensitivity to Danazol or any ingredient in the formulation

Danzol Capsules Precautions

✔ Monitor Liver & Kidney Function: Use cautiously in patients with hepatic or renal disorders.
✔ Cardiovascular Concerns: May cause fluid retention, requiring monitoring in patients with hypertension.
✔ Diabetes Risk: Can alter insulin sensitivity and lipid metabolism.
✔ History of Thrombosis: Should be avoided in individuals with a history of clotting disorders.
✔ Migraine Patients: May exacerbate migraine symptoms.

Danzol Capsules Warnings

⚠ Warning 1: Danazol may cause androgenic effects in infants if used during breastfeeding. Breastfeeding should be discontinued while using this medication.
⚠ Warning 2: Before starting treatment for fibrocystic breast disease, breast cancer must be ruled out.
⚠ Warning 3: Danazol may reduce the efficacy of antihypertensive medications and interact with other gonadal steroid therapies.

Danzol Capsules Additional Information

✔ Pregnancy Category: Not recommended; consult a physician before use.
✔ Storage Instructions: Store at room temperature, away from direct light, moisture, and heat.

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