Endtron Tablets 8mg

Product Overview

• Product Form: Tablets
• Pack Size: 8mg
• Manufactured By: HORIZON PHARMACEUTICALS (PVT) LTD.
• Prescription Required: Yes

Product Details

Endtron Tablets 8mg contain ondansetron, a selective antagonist of the 5-HT3 serotonin receptor. This medication is primarily used to prevent and manage nausea and vomiting associated with chemotherapy and surgery. The exact mechanism by which ondansetron controls chemotherapy-induced nausea and vomiting is not fully understood, but it is believed to block serotonin receptors in the gastrointestinal tract and central nervous system.

Purposes

Endtron Tablets 8mg are indicated for:

• Prevention of Nausea and Vomiting: Particularly effective for nausea and vomiting related to initial and repeat courses of emetogenic cancer chemotherapy.
• Postoperative Care: Used to manage nausea and vomiting following abdominal surgery.

Warnings

• QT Interval Prolongation: Endtron Tablets 8mg may prolong the QT interval, especially at higher doses. Avoid use in patients with congenital long QT syndrome and monitor ECG in those with electrolyte abnormalities or pre-existing heart conditions.
• Abdominal Surgery: In patients who have undergone abdominal surgery, ondansetron might mask symptoms of progressive ileus or gastric distention.
• Non-Peristaltic Action: This medication does not stimulate gastric or intestinal peristalsis and should not replace nasogastric suction if required.

Adverse Effects

Possible side effects of Endtron Tablets 8mg include:

• Common Effects: Headache, constipation, diarrhea, and dizziness.
• Serious Effects: Rare cases of angina, changes in ECG, hypersensitivity reactions such as rash or anaphylaxis, and liver enzyme alterations.
• Neurological: Rare reports of grand mal seizures or oculogyric crisis.

Cautions

• Hypersensitivity: Patients with a known hypersensitivity to ondansetron or similar 5-HT3 receptor antagonists should avoid use. Anaphylaxis and severe allergic reactions have been reported.
• Drug Interactions: Inform your healthcare provider about all medications being taken to avoid interactions with drugs affecting cytochrome P-450 enzymes, serotonergic drugs, and others.
• Pregnancy and Breastfeeding: Consult your physician if you are pregnant, planning to become pregnant, or breastfeeding to ensure this medication is appropriate for you.

Endtron Tablets 8mg provide effective relief from nausea and vomiting, particularly in the context of chemotherapy and postoperative recovery. Use this medication as directed by your healthcare provider to manage symptoms effectively.